20 may. 2014

Seminarios IQFR: "The patchy story of striped nanoparticles: a molecular simulation perspective"


Programa del Ciclo de Seminarios del IQFR 2014



Seminario del  Prof. Lev Sarkisov
Universidad de Edimburgo



"The patchy story of striped nanoparticles: a molecular simulation perspective"




                           Martes 20 de mayo a las 11:00
                     Aula 300 IQFR-CSIC









Resumen:

El  martes 20 de mayo el Prof. Lev Sarkisov de la Universidad de Edimburgo impartirá el seminario titulado:

"The patchy story of striped nanoparticles: a molecular simulation perspective"



Why do some nano-scale objects translocate through lipid membranes and others do not? If we knew the answer to this question, we would be able to assess cytotoxicity of various man-made and natural nanoobjects and also harvest their specific behaviour for antibacterial, drug delivery and other applications.

At the heart of the matter is the way in which nanoparticles (or nanoobjects in general) interact with the biological membranes. Not surprisingly the experimentalists in the field turn to their simulation and theory colleagues to provide an explanation and a clear picture of what is going on at the molecular level.

In this presentation I will review recent feverish attempts to explain the intriguing experimental results of Stellacci and co-workers on striped nanoparticles, which have been shown to be able to effectively tranlocate into fibroblast cells [1,2]. Although, we are still far from a conclusive picture, it is clear that the level of model detail, time and length scale play a crucial role in capturing the phenomena of interest.


1. Verma, A.; Uzun, O.; Hu, Y. H.; Hu, Y.; Han, H. S.; Watson, N.; Chen, S. L.; Irvine, D. J.; Stellacci, F., Surface-structure-regulated cellmembrane penetration by monolayer-protected nanoparticles. Nature Materials 2008, 7, 588-595.

2. Verma, A.; Stellacci, F., Effect of surface properties on nanoparticlecell interactions. Small 2010, 6, 12-21.




Dirección  y como llegar


Fuente:
www.iqfr.csic.es

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